Aerial video from the scene showed several police officers outside the school. Some were searching students and their backpacks.
Angelica Martinez, a 14-year-old student, told CNN she and her schoolmates were being evacuated at one point “like it’s a fire drill.”
“We were all standing (outside), but not even five minutes later, we started hearing gunshots,” she said. “And then everybody starts running, but like the teachers are telling us to stay put, but we’re all just running away.”
“I didn’t see anybody shooting, but like (the gunshots) were kind of spaced,” Angelica said, adding she heard about four shots.
The witness who spoke to KTRK also said she heard an alarm. She didn’t specify if that was before or after the gunfire she described in the art class.
She said she couldn’t describe the shooter.
“I didn’t look. I just ran,” she said.
Another student, Dakota Shrader, told CNN affiliate KPRC that she heard gunshots only after hearing an alarm in the school.
“I was in the history hallway, and as soon as we heard the alarms, everybody just started leaving following the same procedure as … (a) practice fire drill,” Shrader said, breaking into tears. “And next thing you know, we just hear … three gunshots, loud explosions, and all the teachers are telling us to run.”
The entire school district is on lockdown, district officials said.
Santa Fe is a city of about 13,000 people roughly 20 miles northwest of Galveston and 30 miles southeast of Houston.
The high school has about 1,400 students, according to GreatSchools.org.